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Decreased Body Temperature

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...

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Responses to Heat and Cold Stress

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Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.

Thermoregulation

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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...

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Related Experiment Video

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Summary

This summary is machine-generated.

Improper storage of trientene, a copper chelator, can lead to treatment failure in Wilson's disease patients. This case highlights the importance of correct medication temperature for effective copper removal.

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Last Updated: May 31, 2026

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Area of Science:

Neurology
Pharmacology
Metabolic Disorders

Background:

Wilson's disease involves copper accumulation in the basal ganglia, causing movement disorders.
Copper chelation therapy is the standard treatment for Wilson's disease.

Purpose of the Study:

To report a case of Wilson's disease treatment failure due to improper medication storage.
To emphasize the critical role of correct drug storage in therapeutic efficacy.

Main Methods:

A case study of a Wilson's disease patient is presented.
The patient's treatment regimen and medication storage conditions were reviewed.

Main Results:

Treatment with trientene failed to resolve the patient's movement disorder.
Investigation revealed that the trientene medication was stored at an incorrect temperature.

Conclusions:

Incorrect storage temperatures can render copper chelating agents, such as trientene, ineffective.
Adherence to proper pharmaceutical storage guidelines is crucial for successful Wilson's disease management.