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Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets.

Imjak Jeon¹, Tiziana Gilli, Gabriele Betz

¹Department of Pharmaceutical Sciences, Industrial Pharmacy Lab, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

Journal of Pharmacy & Bioallied Sciences

|June 21, 2011

Summary

Roll compaction improves hydroxypropyl cellulose (HPC) matrix tablets, offering better dosage uniformity and faster drug release compared to direct compression. Process parameters like roll pressure and milling speed are key to optimizing tablet properties.

Keywords:

Dry granulation hydroxypropyl cellulose matrix tablet roll compaction sustained release

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Area of Science:

Pharmaceutical Technology
Materials Science

Background:

Hydroxypropyl cellulose (HPC) is utilized in sustained-release matrix tablets.
Traditional tablet manufacturing methods may present challenges with certain excipients like HPC.

Purpose of the Study:

To evaluate roll compaction as a granulation method for hydroxypropyl cellulose (HPC)-based sustained-release matrix tablets.
To compare the properties of roll-compacted tablets with directly compacted tablets.

Main Methods:

Roll compaction was employed for the preparation of HPC-based matrix tablets.
Key process parameters investigated included HPC viscosity grade, roll pressure, and milling speed.
Tablet properties such as dosage uniformity and drug release rate were assessed.

Main Results:

Roll-compacted matrix tablets demonstrated superior dosage uniformity compared to direct-compacted tablets.
Faster drug release profiles were observed in matrix tablets prepared via roll compaction.
HPC viscosity grade, roll pressure, and milling speed significantly influenced the final tablet characteristics.

Conclusions:

Roll compaction is an effective and adequate granulation technique for producing HPC-based sustained-release matrix tablets.
The method offers advantages in process simplicity, handling of tacky HPC, and particle size control.
Optimization of plastic excipient ratios and starting material particle size is crucial for successful roll compaction.