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Collateral drug sensitivity induced in CPT-11 (a novel derivative of camptothecin)-resistant cell lines
1Division of Hematology and Chemotherapy, Chiba Cancer Center Hospital, Japan.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1990
Abstract:
Collateral drug sensitivity was induced in CPT-11-resistant cell lines (CPT-K and T). Ten of the 19 kinds of antineoplastic agents (especially, 5 of 6 kinds of DNA topoisomerase II inhibiting agents) were effective in inducing collateral drug sensitivity. Alteration of DNA topoisomerase I seemed to be unrelated to acquisition of multidrug resistance.