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Associated comorbidities in psoriasis and inflammatory bowel disease
1Clinical Research Program, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Summary
Patients with psoriasis and inflammatory bowel disease (IBD) have higher rates of comorbidities like autoimmune thyroiditis, hepatitis, and diabetes compared to psoriasis-only patients. This highlights shared inflammatory pathways and genetic links in these conditions.
Area of Science:
- Immunology
- Gastroenterology
- Dermatology
Background:
- Psoriasis and inflammatory bowel disease (IBD) share known associations, but detailed comorbidity information remains limited.
- Understanding these comorbidities is crucial for comprehensive patient management.
Purpose of the Study:
- To investigate comorbidities in patients with both psoriasis and IBD.
- To compare these comorbidities with those in patients having psoriasis only.
- To analyze differences within the IBD cohort.
Main Methods:
- A cohort of 146 patients with psoriasis and IBD was compared to 146 patients with psoriasis only.
- Patients were matched for gender, ethnicity, and age.
- Data included socio-demographics, comorbidities, and laboratory inflammation markers (CRP, ESR).
Main Results:
- Patients with both psoriasis and IBD showed significantly higher rates of autoimmune thyroiditis (6.8% vs 2.1%), hepatitis (6.2% vs 0.7%), and diabetes (26.7% vs 11.0%).
- Over 41% of patients with psoriasis and IBD were diagnosed with seronegative arthritis.
- Elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were observed in the psoriasis and IBD group.
Conclusions:
- Patients with co-occurring psoriasis and IBD experience a greater burden of comorbidities.
- Shared inflammatory pathways and genetic predispositions likely contribute to the development of these associated conditions.
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