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Updated: May 31, 2026
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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
Where neuroimaging and lesion studies meet.
1Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy. sze-chai.kwok@st-hughs.oxon.org
Summary
Both lesion studies and functional neuroimaging are essential for understanding cognition. Combining these approaches provides a more complete picture of the brain
Area of Science:
- Neuroscience
- Cognitive Science
Background:
- Lesion studies in patients and animals offer insights into brain function.
- Functional neuroimaging in healthy subjects reveals brain activity patterns.
Purpose of the Study:
- To highlight the complementary nature of lesion and neuroimaging studies.
- To advocate for the integration of both methodologies in cognitive neuroscience research.
Main Methods:
- Review of lesion studies.
- Analysis of functional neuroimaging findings.
- Synthesis of evidence from both study types.
Main Results:
- Lesion studies identify necessary brain regions for specific cognitive functions.
- Functional neuroimaging identifies regions involved in cognitive tasks.
- Each method provides unique, yet incomplete, information.
Conclusions:
- Inferentially sound conclusions about the neural basis of cognition require integrating lesion and neuroimaging data.
- A comprehensive understanding of cognitive neuroscience relies on a multi-modal approach.
