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Updated: May 31, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Systemic treatment for alopecia areata.

¹Skin and Laser Center Potsdam, Hair Clinic, Potsdam, Germany. ninaotberg@gmx.com

Dermatologic Therapy

|June 22, 2011

Summary

Alopecia areata affects 1.7% of the global population, with limited effective treatments for severe cases. This review examines side effects and relapse rates of systemic agents used for severe alopecia areata.

Area of Science:

Dermatology
Immunology

Background:

Alopecia areata (AA) is an autoimmune condition affecting 1.7% of the global population.
The etiology of AA remains largely unknown, and its clinical course is unpredictable.
Current treatments for severe forms like multifocal AA, alopecia totalis, and alopecia universalis are insufficient.

Purpose of the Study:

To review and discuss the side effects of systemic agents used in treating severe and rapidly progressive alopecia areata.
To analyze the relapse rates associated with these systemic treatments for severe alopecia areata.

Main Methods:

Literature review of systemic agents for severe alopecia areata.
Analysis of reported side effect profiles.
Evaluation of relapse data from clinical studies and case reports.

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Main Results:

Systemic agents show variable efficacy but are associated with significant side effects.
Relapse rates are a considerable concern across different treatment modalities.
Data on long-term outcomes and comparative effectiveness is limited.

Conclusions:

Effective and well-tolerated treatments for severe alopecia areata are still needed.
Careful patient selection and monitoring are crucial when using systemic agents.
Further research is required to establish optimal therapeutic strategies for severe alopecia areata.