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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Cirrhosis I: Introduction

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Related Experiment Video

Updated: May 16, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Primary cicatricial alopecias.

Nina Otberg1

  • 1Skin and Laser Center and Hair Transplant Center, Richard-Strauss-Strasse 27, Potsdam, Berlin, Germany. otberg@hlcp.de

Dermatologic Clinics
|November 20, 2012
PubMed
Summary

Primary cicatricial alopecias are rare inflammatory scalp conditions causing permanent hair loss. These diverse disorders can be classified by clinical or histopathologic features.

Area of Science:

  • Dermatology
  • Trichology

Background:

  • Primary cicatricial alopecias (PCAs) are a group of uncommon, idiopathic inflammatory scalp disorders.
  • These conditions lead to irreversible hair loss due to follicular destruction.
  • PCAs can be categorized based on clinical presentation, histopathologic findings, or a combination of both.

Purpose of the Study:

  • To summarize the nature of primary cicatricial alopecias.
  • To highlight the classification methods for these rare scalp disorders.

Main Methods:

  • Review of existing literature and classification systems for primary cicatricial alopecias.
  • Analysis of prevalence data from a specific research center.

Main Results:

  • Primary cicatricial alopecias encompass a diverse range of inflammatory diseases affecting the scalp.

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Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
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Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

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Related Experiment Videos

Last Updated: May 16, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
03:22

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

  • Classification can be achieved through clinical examination and/or histopathologic analysis.
  • A study at Baylor Hair Research and Treatment Center reported a prevalence of 7.3% among patients seeking hair and scalp consultation between 1989 and 1999.

    • Conclusions:

    • Primary cicatricial alopecias are rare but significant scalp conditions characterized by permanent hair loss.
    • Understanding their diverse nature and classification is crucial for diagnosis and management.