Related Experiment Video
Updated: May 31, 2026
05:34
Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders
Published on: August 18, 2023
[Immune function changes in patients with obstructive sleep apnea hypopnea syndrome]
Zheng-gong Li1, Tao-ping Li, Hong Ye
1Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. 522686296@qq.com
Summary
Patients with obstructive sleep apnea hypopnea syndrome (OSAHS) show altered immune function. Specifically, OSAHS is linked to decreased IgM and NK cells, indicating impaired humoral and cellular immunity.
Area of Science:
- Immunology
- Sleep Medicine
- Respiratory Medicine
Context:
- Obstructive sleep apnea hypopnea syndrome (OSAHS) is a prevalent condition affecting respiratory and cardiovascular health.
- Immune system dysregulation is increasingly recognized as a factor in sleep disorders.
- Understanding immune changes in OSAHS is crucial for comprehensive patient management.
Purpose:
- To investigate alterations in humoral and cellular immunity in patients diagnosed with OSAHS.
- To compare immune profiles of OSAHS patients against healthy controls.
Summary:
- A retrospective study of 187 OSAHS patients and 20 controls revealed significant immune changes.
- OSAHS patients exhibited elevated C3 levels and reduced IgM and NK cell percentages.
- Immune markers correlated with sleep apnea severity (AHI) and oxygen saturation (LSpO2).
Impact:
- Findings suggest that OSAHS is associated with compromised humoral and cellular immune functions.
- These immune alterations may contribute to the systemic complications of OSAHS.
- Highlights the need for further research into immune modulation as a therapeutic target for OSAHS.
Related Concept Videos
01:21Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
01:22Heart Failure VI: Adjunct Therapies
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
01:27Physical Assessment of the Respiratory Tract II: Inspection
Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration can...
Chest Configuration
The chest configuration can...
01:17Other Pulmonary Disorders
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation