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Updated: May 31, 2026
09:19
Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury
Published on: May 7, 2015
Renal perfusion evaluation with contrast-enhanced ultrasonography
Antoine G Schneider1, Lucie Hofmann, Grégoire Wuerzner
1Department of Internal Medicine, Division of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Summary
Contrast-enhanced ultrasonography (CEUS) can quantify renal perfusion changes. This novel imaging technique shows promise in assessing renal function by correlating perfusion indices with effective renal plasma flow.
Area of Science:
- Nephrology
- Medical Imaging
- Physiology
Background:
- Contrast-enhanced ultrasonography (CEUS) is a safe, bedside imaging modality.
- CEUS has emerging capabilities for quantifying organ perfusion.
- This study explored CEUS for detecting renal perfusion changes.
Purpose of the Study:
- To determine CEUS's ability to detect changes in renal perfusion.
- To correlate CEUS-derived perfusion indices with effective renal plasma flow (ERPF).
Main Methods:
- CEUS with destruction-refilling sequences in 10 healthy subjects.
- Measurements taken at baseline, during angiotensin II infusion (low and high dose), and after captopril administration.
- Perfusion index (PI) calculated and compared with ERPF via para-aminohippurate (PAH) clearance.
Main Results:
- Angiotensin II infusion significantly decreased median PI (-47% low dose, -65% high dose) and ERPF (-15% low dose, -36% high dose).
- Captopril administration increased median PI (+35%) and ERPF (+4%).
- Changes in PI closely paralleled changes in ERPF across all conditions.
Conclusions:
- CEUS effectively detects alterations in human renal cortical microcirculation.
- CEUS-derived perfusion indices correlate with ERPF measurements.
- CEUS shows potential for non-invasive renal perfusion assessment.
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