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Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

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Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
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Updated: May 31, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Angiogenesis in peritoneal dialysis.

A W D Stavenuiter1, M N Schilte, P M Ter Wee

  • 1Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands. a.stavenuiter@vumc.nl

Kidney & Blood Pressure Research
|June 22, 2011
PubMed
Summary
This summary is machine-generated.

Long-term peritoneal dialysis (PD) fluid exposure causes blood vessel growth (angiogenesis) and reduces fluid removal (ultrafiltration). Interventions like sunitinib show promise in preventing this in rats, but clinical trials are needed.

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A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
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Area of Science:

  • Nephrology
  • Vascular Biology
  • Cell Biology

Background:

  • Peritoneal dialysis (PD) fluid exposure causes morphological changes in the peritoneum.
  • Angiogenesis, or new blood vessel formation, is a key alteration linked to reduced ultrafiltration (UF) capacity.

Purpose of the Study:

  • To discuss factors influencing angiogenesis during PD.
  • To describe the cellular mechanisms of PD-induced angiogenesis.
  • To review interventions for decreasing angiogenesis in PD and present new data on sunitinib.

Main Methods:

  • Review of factors affecting PD-induced angiogenesis.
  • Description of the angiogenesis process and cell roles in the peritoneum.
  • Evaluation of interventions in a rat PD model, including sunitinib administration.

Main Results:

  • Long-term PD fluid exposure leads to angiogenesis and UF loss.
  • Several interventions show potential in reducing angiogenesis in a rat model.
  • Sunitinib demonstrates efficacy in inhibiting angiogenesis in the rat PD model.

Conclusions:

  • Preventing angiogenesis is crucial for maintaining UF capacity in PD patients.
  • Further well-randomized clinical trials are necessary to confirm the efficacy of interventions.
  • Future PD treatment strategies should target angiogenesis, peritoneal fibrosis, and inflammation.