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06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Type 1 diabetes mellitus and celiac disease: endothelial dysfunction
Antonio Picarelli1, Marco Di Tola, Luigi Sabbatella
1Department of Internal Medicine and Medical Specialities, Center for Research and Study of Celiac Disease, Sapienza University, Rome, Italy.
Acta Diabetologica
|June 22, 2011
Summary
Type 1 diabetes patients with celiac disease showed improved metabolic control and reduced blood clotting factors. This suggests celiac disease may protect against the prothrombotic state in diabetes.
Area of Science:
- Endocrinology and Metabolism
- Hematology
- Gastroenterology
Background:
- Diabetes mellitus, particularly type 1 (DM1), is associated with a hypercoagulative state due to endothelial damage.
- A known association exists between type 1 diabetes mellitus and celiac disease.
- The impact of co-occurring celiac disease on the hemostatic system and microvascular complications in DM1 patients is not well understood.
Purpose of the Study:
- To investigate the hemostatic system and microvascular complications in type 1 diabetes patients with and without celiac disease.
- To determine if celiac disease influences the expression of hemostatic factors and the progression of microvascular issues in DM1.
Main Methods:
- Ninety-four adult type 1 diabetes patients were screened for celiac disease using anti-endomysial antibodies (EMA).
- Celiac disease diagnosis was confirmed by histology and organ culture.
- Hemocoagulative parameters, metabolic control (HbA1c), and microvascular complications were compared between DM1 patients with and without celiac disease.
Main Results:
- DM1 patients with celiac disease exhibited significantly lower HbA1c, cholesterol, triglycerides, factor VII antigen (FVII:ag), factor VII coagulant activity (FVII:c), and prothrombin degradation fragments (F1+2).
- These patients also showed significantly higher levels of activated protein C (APC).
- No retinal abnormalities or renal damage were observed in DM1 patients with celiac disease.
Conclusions:
- Celiac disease may exert a protective effect against the prothrombotic state commonly observed in type 1 diabetes.
- The presence of celiac disease in DM1 patients is associated with improved metabolic control and a less thrombogenic profile.
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