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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: May 31, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep brain stimulation for psychiatric disorders.

Paul E Holtzheimer1, Helen S Mayberg

  • 1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA. pholtzh@emory.edu

Annual Review of Neuroscience
|June 23, 2011
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) offers a promising focal neuromodulation approach for psychiatric disorders, addressing limitations of current treatments with preliminary safety and efficacy data. Further research explores its potential for improved patient outcomes.

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Last Updated: May 31, 2026

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurosurgery

Background:

  • Current psychiatric treatments show limitations, with many patients experiencing incomplete symptom resolution and high relapse rates.
  • Focal neuromodulation, particularly deep brain stimulation (DBS), is gaining interest due to advances in neuroanatomy and neural activity modulation.
  • DBS is an established treatment for movement disorders, with emerging data for psychiatric applications.

Purpose of the Study:

  • To review the rationale and development for testing deep brain stimulation (DBS) in psychiatric disorders.
  • To critically evaluate the existing clinical data on DBS for psychiatric conditions.
  • To discuss potential mechanisms of action for DBS in treating psychiatric disorders.

Main Methods:

  • Review of existing literature on deep brain stimulation (DBS) for psychiatric disorders.
  • Analysis of preliminary clinical data regarding safety and efficacy.
  • Exploration of neuroanatomical models and neural activity modulation strategies.

Main Results:

  • Preliminary data suggest potential safety and efficacy of DBS for several psychiatric disorders.
  • DBS represents a focal neuromodulation technique with a growing evidence base.
  • The development of DBS for psychiatric use is supported by improved understanding of brain regulation.

Conclusions:

  • Deep brain stimulation (DBS) is a developing focal neuromodulation technique with potential for treating psychiatric disorders.
  • Existing data, while preliminary, support further investigation into DBS for psychiatric conditions.
  • Understanding the mechanisms of action is crucial for optimizing DBS therapy in psychiatry.