Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Appendicitis

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

Cardiomyopathy IV: Restrictive Cardiomyopathy

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

Smooth Endoplasmic Reticulum

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of Selected Cereal Concentrates and a Gluten-Free Diet on Ovarian, Testicular, and Thyroid Gland Morphology.

Physiological research·2026

Same author

Cyclin D1 rearranged diffuse large B-cell lymphoma-an evolving concept.

Leukemia·2025

Same author

Udder morphology and milk yield of Lacaune dairy sheep.

Schweizer Archiv fur Tierheilkunde·2025

Same author

Idiopathic Pulmonary Fibrosis: Review of Current Knowledge.

Physiological research·2024

Same author

Mastitis in a flock of milking sheep.

Schweizer Archiv fur Tierheilkunde·2023

Same author

Intrapulmonary sequestration with destructive pneumonia and life-threatening hemoptysis in an adult patient: a case report.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2023

Search research articles

Related Experiment Video

Updated: May 31, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

[Morbus Ormond (idiopatic retroperitoneal fibrosis)].

A Michaligová¹, L Plank, A Jezíková

¹I. Interná klinika Jesseniovej lekárskej fakulty UK a Univerzitnej nemocnice Martin, Slovenská republika. michaligova@gmail.com

Vnitrni Lekarstvi

|June 24, 2011

Summary

Idiopathic retroperitoneal fibrosis (IRF) is a rare condition affecting the aorta. This case report details a 37-year-old male diagnosed with IRF, also known as Morbus Ormond, presenting with fever and inflammation.

Related Experiment Videos

Last Updated: May 31, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Area of Science:

Nephrology
Vascular Surgery
Radiology

Background:

Idiopathic retroperitoneal fibrosis (IRF) is a rare fibrotic condition typically affecting the abdominal aorta and iliac arteries, often involving adjacent structures like ureters and the inferior vena cava.
IRF commonly presents in individuals aged 40-60, with a male predominance, and frequently manifests as ureteral obstruction.
The condition, also known as Morbus Ormond, is characterized by extensive retroperitoneal fibrosis of unknown etiology.

Observation:

A 37-year-old male presented with persistent fever (approx. 38°C) and elevated inflammatory markers despite empirical antibiotic treatment.
Positron emission tomography (PET) revealed localized, hypermetabolic activity of fluorodeoxyglucose (FDG) predominantly in the left para-aortic region.
Microscopic examination of an extracted retroperitoneal mass confirmed the presence of fibrous and inflammatory components.

Findings:

The clinical presentation, imaging findings (PET scan), and histological analysis were consistent with a diagnosis of idiopathic retroperitoneal fibrosis.
The patient's younger age at onset (37 years) is noteworthy compared to the typical age range for IRF.
The para-aortic location of the fibrotic process was clearly identified through PET imaging.

Implications:

This case highlights the importance of considering IRF in younger patients presenting with unexplained fever and elevated inflammatory markers, even without classic ureteral compression symptoms.
Advanced imaging techniques like PET-CT are crucial for localizing the fibrotic process and aiding in diagnosis.
Accurate diagnosis of IRF is essential for appropriate management and to differentiate it from other retroperitoneal masses or inflammatory conditions.