Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

cGAMP-Loaded M2e Nanovaccine Elicits Cross-Reactive Immunity and Mitigates H6N1 Avian Influenza Infection in Chickens.

International journal of nanomedicine·2026
Same author

Translational bottlenecks for biohybrid microrobots.

Science robotics·2026
Same author

Light-switchable swarming of biohybrid microrobots.

Science advances·2026
Same author

A STING-adjuvanted outer membrane vesicle nanoparticle vaccine vs. <i>Klebsiella pneumoniae</i> elicits broad capsule-type cross-protection.

PNAS nexus·2026
Same author

Integrating Experiments and Simulations to Uncover Size-Dependent Bioactivity in Cellular Nanodiscs.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Mesoscopic Inhomogeneities in Ethanol-Water Mixtures: Are They Nanobubbles, Impurity Aggregates, or Nanoscale Gas-Water Composite Structures?

Langmuir : the ACS journal of surfaces and colloids·2026

Related Experiment Video

Updated: May 31, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy.

Santosh Aryal1, Che-Ming Jack Hu, Liangfang Zhang

  • 1Department of NanoEngineering, University of California, San Diego, La Jolla, California 92093-0815, USA.

Molecular Pharmaceutics
|June 24, 2011
PubMed
Summary

This study introduces a novel nanoparticle drug delivery system for combination chemotherapy. The system precisely controls the ratio of two drugs, doxorubicin and camptothecin, within a single nanoparticle, enhancing treatment efficacy.

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

Related Experiment Videos

Last Updated: May 31, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Combination chemotherapy requires precise control over drug ratios for optimal efficacy.
  • Existing drug delivery vehicles struggle with simultaneous loading of multiple drugs at controlled ratios.

Purpose of the Study:

  • To develop a novel nanoparticle system for concurrent delivery of two chemotherapy drugs with ratiometric control.
  • To synthesize and characterize dual-drug loaded polymeric nanoparticles using drug-polymer conjugates.

Main Methods:

  • Synthesis of hydrophobic drug-poly-L-lactide (drug-PLA) conjugates using metal alkoxide chemistry.
  • Encapsulation of drug-PLA conjugates into lipid-coated polymeric nanoparticles via single-step nanoprecipitation.
  • Characterization of nanoparticle size, surface charge, and drug loading efficiency.

Main Results:

  • Achieved over 90% loading efficiency for doxorubicin (DOX) and camptothecin (CPT) in nanoparticles.
  • Demonstrated precise control over DOX:CPT loading ratios by adjusting conjugate ratios.
  • Dual-drug nanoparticles exhibited superior cellular cytotoxicity compared to single-drug nanoparticles or cocktail mixtures.

Conclusions:

  • The developed nanoparticle system offers a viable solution for ratiometric control in dual-drug delivery.
  • This approach holds potential for combinatorial cancer treatments using various hydroxyl-containing chemotherapeutic agents.