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Updated: May 31, 2026
Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
Published on: February 19, 2020
Sodium and chloride channelopathies with myositis: coincidence or connection?
Emma Matthews1, James A L Miller, Malcolm R MacLeod
1Medical Research Council Centre for Neuromuscular Disease, UCL, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Introduction:
A proximal myopathy develops in some patients with muscle channelopathies, but the causative molecular mechanisms are unknown.
Methods:
We reviewed retrospectively all clinical and muscle biopsy findings of 3 patients with channelopathy and additional myositis. Direct DNA sequencing was performed.
Results:
Pathogenic mutations were identified in each case. Biopsies demonstrated inflammatory infiltrates.
Conclusions:
Clinicians should consider muscle biopsy in channelopathy patients with severe myalgia and/or subacute weakness and accompanying elevated creatine kinase. Chance association of myositis and channelopathy is statistically unlikely. An alternative hypothesis suggests that inflammatory insults could contribute to myopathy in some patients.
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