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Updated: May 31, 2026

Fast Grid Preparation for Time-Resolved Cryo-Electron Microscopy
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Fast Grid Preparation for Time-Resolved Cryo-Electron Microscopy

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Quick saturation of a cotton tip applicator using a handheld cryosurgical spray device

James O Barlow

    Cutis
    |June 25, 2011
    PubMed
    Summary

    No abstract available in PubMed .

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    Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...