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Published on: November 1, 2016
Conducting polymer nanowires-based label-free biosensors
Ashok Mulchandani1, Nosang V Myung
1Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, United States. adani@engr.ucr.edu
Current Opinion in Biotechnology
|June 25, 2011
Summary
Label-free biosensors using conducting polymer nanowires offer sensitive, rapid analysis for healthcare and environmental monitoring. This review covers their fabrication, functionalization, and sensing applications, highlighting advantages and disadvantages.
Area of Science:
- Nanotechnology
- Materials Science
- Biosensing
Background:
- Label-free sensing technologies are crucial for rapid analysis in healthcare, environmental monitoring, food safety, and security.
- One-dimensional (1-D) nanostructures, like nanowires, configured as field-effect transistors (FETs)/chemiresistors are highly attractive for label-free biosensors due to conductance changes upon target binding.
Purpose of the Study:
- To review recent advancements in label-free biosensors utilizing conducting polymer nanowires in FET/chemiresistor configurations.
- To discuss the fabrication, functionalization, assembly/alignment, and sensing applications of these nanomaterial-based nanosensors.
Main Methods:
- Review of literature on conducting polymer nanowire fabrication techniques.
- Analysis of functionalization strategies for receptor immobilization on nanowire surfaces.
- Discussion of assembly and alignment methods for creating FET/chemiresistor devices.
- Evaluation of sensing performance and applications in various domains.
Main Results:
- Conducting polymer nanowire FETs/chemiresistors demonstrate significant potential for sensitive and rapid label-free detection.
- Various fabrication and functionalization methods offer distinct advantages and disadvantages impacting sensor performance.
- Effective assembly and alignment are critical for optimal device function and reproducibility.
Conclusions:
- Label-free biosensors based on conducting polymer nanowires are a promising technology for diverse analytical applications.
- Understanding the trade-offs in fabrication, functionalization, and assembly is key to optimizing nanosensor design.
- Continued research in these areas will drive further development and adoption of these advanced sensing platforms.
