Hematuria evaluation with MDCT urography: is a contrast-enhanced phase needed when calculi are detected in the unenhanced phase?
Related Experiment Video
Updated: May 31, 2026

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
Published on: June 21, 2024
Julie H Song1, Michael D Beland, William W Mayo-Smith
1Department of Diagnostic Imaging, Rhode Island Hospital-Warren Alpert Medical School of Brown University, Providence, 02903, USA. jsong2@lifespan.org
Insights
The contrast-enhanced phase of multi-detector CT urography (MDCTU) is crucial for diagnosing hematuria, even when urinary tract calculi are present. This phase helps identify other potential causes of bleeding not visible on unenhanced scans.
Area of Science:
- Radiology
- Urology
- Medical Imaging
Background:
- Hematuria is a common clinical presentation.
- Multi-detector CT urography (MDCTU) is frequently used for hematuria evaluation.
- The role of the contrast-enhanced phase in MDCTU when calculi are present requires further clarification.
Purpose of the Study:
- To determine the added diagnostic value of the contrast-enhanced phase of MDCTU when urinary tract calculi are identified in the unenhanced phase.
- To assess if the detection rate of alternative hematuria sources differs between MDCTU with and without calculi.
Main Methods:
- Retrospective review of 1209 MDCTU reports for patients presenting with hematuria.
- Identification of 286 examinations with detected urinary tract calculi.
- Blinded review by two abdominal radiologists to identify a second source of hematuria, comparing unenhanced and contrast-enhanced phases.
- Follow-up diagnosis based on histopathology, urologic procedures, or imaging.
Main Results:
- In 10% of patients, lesions other than calculi were identified as potential hematuria sources.
- A second source of hematuria was found in 7% of examinations with calculi versus 6% without (p=0.828).
- Contrast enhancement was necessary for a specific diagnosis in 84% of examinations where a second source was identified.
Conclusions:
- The detection rate of other potential hematuria causes is similar whether or not urinary tract calculi are present.
- The contrast-enhanced phase of MDCTU is essential, even with visible calculi, as it aids in diagnosing significant pathologic changes.
- Contrast-enhanced MDCTU is valuable for comprehensive hematuria evaluation, regardless of initial calculus findings.
Objective:
The purpose of this study was to assess the added utility of the contrast-enhanced phase of MDCT urography (MDCTU) when urinary tract calculi are detected in the preliminary unenhanced phase.
Materials And Methods:
A computer search of CT reports with the term "hematuria" yielded the records of 1209 patients who had undergone MDCTU. The reports of 286 MDCTU examinations in which urinary tract calculi were detected were identified, and two blinded abdominal radiologists reviewed the images to find a second source of hematuria. The unenhanced images were reviewed first, and the findings were compared with those on the subsequent contrast-enhanced images. The aggregate findings of the 286 examinations in which calculi were present were compared with those of the 923 examinations in which calculi were absent. The follow-up diagnosis was based on histopathologic findings, findings at urologic procedures, or the imaging diagnosis.
Results:
In 119 of the 1209 patients (10%), 127 lesions other than urinary tract calculi were identified as possible sources of hematuria. Eighty-two lesions were diagnosed in 77 patients (6%) at follow-up evaluation. A second source of hematuria was found in 19 of the 286 examinations (7%) with calculi compared with 58 of the 923 examinations (6%) without calculi (p = 0.828), and contrast was needed to make a specific diagnosis in 16 of the 19 examinations (84%).
Conclusion:
When urinary tract calculi are identified at MDCTU, the rate of detection of other potential causes of hematuria is not different from that in MDCTU examinations without calculi. The contrast-enhanced portion of the MDCTU examination is needed even if calculi are seen because important pathologic changes are diagnosed only after the contrast-enhanced phase.
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