Related Experiment Video

Updated: May 31, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Levels of soluble triggering receptor expressed on myeloid cells 1 in infectious exacerbations of chronic obstructive

Gernot Rohde1, Markus P Radsak, Irmgard Borg

  • 1Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands. g.rohde@mumc.nl

Respiration; International Review of Thoracic Diseases
|June 25, 2011
PubMed
Abstract

Insights

Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is elevated in COPD patients but not specifically in acute exacerbations. Viral infections during exacerbations are associated with lower sTREM-1 levels.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Biomarker Research

Background:

  • Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is an inflammatory cell receptor upregulated by microbial products.
  • Elevated sTREM-1 levels are linked to sepsis, severe pneumonia, and chronic obstructive pulmonary disease (COPD).

Purpose of the Study:

  • To determine the role of sTREM-1 in acute exacerbations of COPD (AE-COPD).
  • To assess sTREM-1's ability to differentiate between infectious triggers in AE-COPD.

Main Methods:

  • Prospective recruitment of smokers without COPD (SM), stable COPD (sCOPD) patients, and AE-COPD patients.
  • Quantification of serum sTREM-1 levels using ELISA.
  • Detection of bacterial pathogens via sputum culture and respiratory viruses via PCR.

Main Results:

  • sTREM-1 levels were significantly higher in sCOPD and AE-COPD patients compared to SM.
  • No significant difference in sTREM-1 was observed between sCOPD and AE-COPD patients.
  • AE-COPD patients with viral detection showed significantly lower sTREM-1 levels than those without viral detection.

Conclusions:

  • sTREM-1 is elevated in COPD patients but not specifically during acute exacerbations compared to stable COPD.
  • Lower sTREM-1 levels in AE-COPD are associated with viral infections, suggesting a potential role in differentiating exacerbation causes.

More Related Videos

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF107:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury08:27

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Published on: May 21, 2018

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...