Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 31, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Chorioamnionitis - new ideas from experimental models.

Boris W Kramer¹

¹Division of Neonatology, Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands. b.kramer@mumc.nl

|June 25, 2011

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neonatal Hypoglycemia: A Systematic Review of International and Local Clinical Guidelines with Clinical Implications.

Journal of clinical medicine·2026

Same author

Less Invasive Surfactant Administration in Extreme Preterm Infants: A Systematic Review and Meta-Analysis.

Neonatology·2026

Same author

The Umbilical Cord Clamp Method-Procedural Description and Safety Assessment of a Novel Method of Umbilical Catheter Fixation After Side Entry Insertion.

Life (Basel, Switzerland)·2025

Same author

Seasonal Patterns of Preterm Birth During the COVID-19 Pandemic: A Retrospective Cohort Study in Romania.

Medicina (Kaunas, Lithuania)·2025

Same author

Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes.

Cells·2025

Same author

An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains.

Nature neuroscience·2025

Same journal

Prospective economic evaluation ancillary to a trial of higher versus lower hemoglobin transfusion thresholds for preterm infants.

Neonatology·2026

Same journal

Mechanisms of Injury From Environmental Exposures in the Neonatal Intensive Care Unit Impacting Neurodevelopmental Outcomes for Neonates.

Neonatology·2026

Same journal

The Effect of Liberal versus Restrictive Haemoglobin Thresholds on Cerebral Tissue Oxygenation in Preterm Infants: A Systematic Review and Meta-Analysis.

Neonatology·2026

Same journal

Early Total vs Conventional Feeding between 27-32 weeks' gestation: A Randomized Controlled Trial.

Neonatology·2026

Same journal

Early Metabolic Alterations are Associated with Intraventricular Hemorrhage and Its Complications in Very Preterm Infants.

Neonatology·2026

Same journal

Comparative Diagnostic Performance of Early and Term MRI in Preterm Infants: a Diagnostic Test Accuracy Systematic review and Bayesian Meta-analysis.

Neonatology·2026

See all related articles

Antenatal inflammation, like chorioamnionitis, can harm newborns. This study used sheep models to show lipopolysaccharide (LPS) and Ureaplasma infections cause organ damage and immune changes, highlighting the need for further research.

Area of Science:

Reproductive biology
Neonatal immunology
Fetal medicine

Background:

Antenatal inflammation is linked to adverse neonatal outcomes.
Microbial invasion of the amniotic cavity, known as chorioamnionitis, involves bacteria and viruses.
Causes, onset timing, and fetal responses in chorioamnionitis require further elucidation.

Purpose of the Study:

To investigate the effects of induced chorioamnionitis on fetal organ systems and systemic responses in a sheep model.
To explore the distinct impacts of lipopolysaccharide (LPS) and Ureaplasma species on fetal development and inflammation.
To identify potential therapeutic targets by understanding the mechanisms of inflammation and damage.

Main Methods:

Chorioamnionitis was induced in pregnant sheep via amniotic cavity injections of lipopolysaccharide (LPS) or Ureaplasma species.

More Related Videos

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Related Experiment Videos

Last Updated: May 31, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Ultrasound guidance was employed for accurate injections.

Organ-specific and systemic effects were assessed following induced infections.

Main Results:

LPS-induced chorioamnionitis led to a cascade of organ injury, inflammation, and remodeling, with associated systemic effects.
Systemic effects of LPS exposure included immune suppression (cross-tolerance) to Toll-like receptor agonists.
Ureaplasma-induced chorioamnionitis resulted in time-dependent alterations in fetal lung structure.

Conclusions:

Induced chorioamnionitis in a sheep model replicates key aspects of human disease, providing a valuable research platform.
Lipopolysaccharide and Ureaplasma infections elicit distinct inflammatory and structural responses in the fetus.
Further research into the mechanisms of inflammation, structural damage, and growth factor expression is crucial for developing therapeutic strategies.