Long-term lead elimination from plasma and whole blood after poisoning
Gerda Rentschler1, K Broberg, T Lundh
1Division of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Gerda.Rentschler@med.lu.se
Objective:
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
Methods:
A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
Results:
P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
Conclusion:
P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
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