The metabotrophic NGF and BDNF: an emerging concept

Area of Science:

• Neuroscience
• Metabolic Biology
• Cardiovascular Science

Background:

• Neurotrophins, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), are known for diverse biological roles.
• Recent research has expanded their functions beyond neurotrophic effects to include immunotrophic, epitheliotrophic, and nociceptive actions.

Observation:

• The concept of 'metabotrophicity' proposes that NGF and BDNF are involved in maintaining cardiometabolic homeostasis.
• Alterations in NGF and BDNF levels are observed in various cardiometabolic diseases such as obesity, type 2 diabetes, and metabolic syndrome.

Findings:

• A metabotrophic deficit, characterized by reduced NGF/BDNF availability or utilization, is hypothesized to contribute to the pathogenesis of cardiometabolic diseases.
• This deficit may underlie conditions like atherosclerosis, obesity, type 2 diabetes, metabolic syndrome, and potentially 'type 3 diabetes'.

Implications:

• The findings suggest a novel understanding of the role of neurotrophins in metabolic regulation.
• This research opens new pathways for developing therapeutic strategies targeting NGF and BDNF for cardiometabolic disorders.