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Published on: June 2, 2014

Plasma homocysteine in patients of migraine without aura

Faraz Ahmed Bokhari1, Tania A Shakoori, Syed Ahmad A Hassan

  • 1Department of Physiology, University of Health Sciences/Federal Postgraduate Medical Institute, Shaikh Zayed Medical Complex, Lahore, Pakistan. drfarazbokhari@yahoo.com

Journal of Ayub Medical College, Abbottabad : JAMC
|June 28, 2011
PubMed
Abstract

Insights

This study found higher homocysteine levels in migraine patients, particularly those with migraine without aura. While the MTHFR C677T variant may be linked to migraine, it did not correlate with homocysteine levels in this population.

Area of Science:

  • Neurology
  • Genetics
  • Biochemistry

Background:

  • Conflicting results exist regarding homocysteine levels in migraineurs.
  • The MTHFR C677T genotype is potentially linked to increased migraine risk.

Purpose of the Study:

  • To assess the association between the MTHFR C677T variant and migraine.
  • To determine the correlation between homocysteine levels and migraine.
  • To investigate the relationship between the MTHFR C677T variant and homocysteine levels in migraineurs.

Main Methods:

  • A pilot study involving 27 adult migraineurs (with and without aura) and 32 controls.
  • Analysis of homocysteine levels and MTHFR C677T genotype in participants.
  • Statistical analysis including Kruskal-Wallis test and ANOVA.

Main Results:

  • Significant differences in homocysteine levels were observed across diagnostic groups (p=0.005).
  • Homocysteine levels were significantly higher in both migraine with aura (MWA) and migraine without aura (MWOA) groups compared to controls.
  • A significant association was found between the migraine group and the C677T-MTHFR variant mutant allele (p=0.039), but not between the variant and homocysteine levels.

Conclusions:

  • Plasma homocysteine levels are significantly associated with migraine without aura.
  • Plasma homocysteine levels were lower in migraine with aura than in migraine without aura.
  • No relationship was found between homocysteine levels and the MTHFR C677T variant (SNP rs1801133), but a potential link between the variant and migraine exists in this population.

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