Related Experiment Video
Updated: May 31, 2026

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
Published on: May 30, 2025
Spice: a legal marijuana equivalent
Lucas A Johnson1, Rebecca L Johnson, Chris Alfonzo
1III Marine Headquarters Group, III Marine Expeditionary Force, Unit 35640, FPO AP 96606-5640.
Spice, a synthetic cannabinoid herbal mixture, is increasingly abused by young adults for narcotic effects. Limited literature exists on its clinical impact, with a case report on psychosis highlighting this knowledge gap.
Area of Science:
- Toxicology
- Psychiatry
- Pharmacology
Background:
- Spice, an herbal mixture containing synthetic cannabinoids, is a legal drug.
- Increasing abuse is noted among adolescents and young adults.
- The drug produces narcotic-like effects.
Observation:
- A paucity of English language literature exists on the clinical effects of Spice use.
- This study includes a case report of substance-induced psychosis.
- A summary of available literature on Spice is presented.
Findings:
- Synthetic cannabinoid use can lead to substance-induced psychosis.
- Clinical effects of Spice are not well-documented in English literature.
- Adolescents and young adults are a key demographic for Spice abuse.
Implications:
- Further research is needed to understand the clinical effects and risks of Spice.
- Healthcare providers should be aware of potential psychosis associated with Spice use.
- Public health initiatives may be necessary to address adolescent and young adult abuse of synthetic cannabinoids.
More Related Videos
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Hallucinogens and Psychedelics
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
An Overview of Psychoactive Drugs
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
CNS Stimulants: Psychedelic Agents
Drug Regulation

