Related Experiment Video
Updated: May 31, 2026
Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture
Published on: December 22, 2016
Evidence of a pharmacodynamic EEG profile in rats following clonidine administration using a nonlinear analysis
David-Olivier D Azulay1, Benjamin Renoux, Magnus Ivarsson
1Pfizer Global Research and Development, Ramsgate Road, Sandwich, CT13 9NJ, UK. david-olivier.azulay@wanadoo.fr.
Background:
Changes caused by clonidine in rodent electroencephalograms (EEG) have been reported with some inconsistency. For this reason, a pre-clinical study was conducted in order to confirm previous findings with both a standard spectral analysis and a sleep stage scoring procedure. In addition, a nonlinear technique for analysing the time-varying signals was implemented to compare its performance against conventional approaches.
Results:
The nonlinear method succeeds in quantifying all dose-related responses from the data set relying solely on the EEG trace.
Conclusions:
Nonlinear approaches can deliver a suitable alternative to the sleep-stage scoring methods commonly used for drug effect detection.
