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Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
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Varicocele and epididymitis in Behcet disease.

Omer Yilmaz1, Sedat Yilmaz, Bunyamin Kisacik

  • 1Division of Radiology, Gulhane School of Medicine, Etlik, 06018 Ankara, Turkey. droyilmazrad@hotmail.com

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|June 28, 2011
PubMed
Summary

The incidence of varicocele, a vein dilation, is higher in patients with Behçet disease. Further research is needed to understand the fertility implications and mechanisms behind this association.

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Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Urology

Background:

  • Behçet disease is a systemic inflammatory disorder characterized by vasculitis affecting various blood vessels.
  • Varicocele, the dilation of pampiniform plexus veins, is a common condition in males.

Purpose of the Study:

  • To determine the incidence of varicocele in male patients diagnosed with Behçet disease.
  • To compare varicocele prevalence between Behçet disease patients and healthy controls.

Main Methods:

  • A cohort of 47 male Behçet disease patients and 31 healthy controls underwent clinical evaluation and scrotal examinations.
  • Color Doppler ultrasonography was used by blinded investigators to measure pampiniform plexus vein diameters and diagnose varicoceles.

Main Results:

  • Left varicocele was diagnosed in 55.3% of Behçet disease patients versus 29% of controls (P = .02).
  • Clinical scrotal abnormalities were more frequent in Behçet disease patients (51.1%) compared to controls (16.1%; P = .002).
  • Epididymitis was observed in 17% of Behçet disease patients but none of the controls (P = .019).

Conclusions:

  • The prevalence of varicocele is significantly increased in individuals with Behçet disease.
  • The clinical significance of varicocele in Behçet disease, particularly regarding fertility, requires further investigation.
  • The underlying mechanisms linking Behçet disease and varicocele remain to be elucidated.