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Updated: May 31, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Facile Access to Hydroxy-Functional Core-Shell Microspheres via Grafting of Ethylene Oxide by Anionic Ring-Opening
Raymond Joso1, Stefan Reinicke, Andreas Walther
1Centre for Advanced Macromolecular Design, University of New South Wales, Sydney NSW 2052, Australia.
Abstract:
We present a facile access route to hydroxy-functional narrow disperse microspheres of well-defined grafting density (GD). Ethylene oxide has been grafted from highly crosslinked poly(divinyl benzene) microspheres by anionic ring-opening polymerization using sec-butyllithium as activator together with the phosphazene base t-BuP(4) . Initially, core microspheres have been prepared by precipitation polymerization utilizing divinyl benzene (DVB, 80 wt.-%). The grafting of poly(ethylene oxide) (PEO) from the surface resulted in the formation of functional core-shell microspheres with hydroxy-terminal end groups. The number average particle diameter of the grafted microspheres was 3.6 µm and the particle weight increased by 5.7%. The microspheres were characterized by SEM, FT-IR spectroscopy, elemental analysis, and fluorescence microscopy. The surface GD (determined via two methods) was 1.65 ± 0.06 and 2.09 ± 0.08 chains · nm(-2) , respectively.
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