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Published on: May 20, 2019
Polymers and Sulfur: what are Organic Polysulfides Good For? Preparative Strategies and Biological Applications
Cong Duan Vo1, Giona Kilcher, Nicola Tirelli
1Laboratory of Polymers and Biomaterials, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Abstract:
Sulfur(II)-containing polymers (polysulfides) combine flexible synthetic and processing techniques with a unique responsiveness to oxidants. Here, the polysulfide oxidative sensitivity is put into the biological context of the development of new anti-inflammatory therapies - the development of new anti-inflammatory methodologies, adopted interactions and the minimisation of foreign-body reactions - through the review of 50 years of research on polysulfide synthetic methodologies. Attention is paid to the identification of the most flexible and robust preparative techniques.
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