Programming Degradation and Drug Release Through Micropatterning of PLGA Films

Irene Guerriero1,2, Cristiano Pesce1,3, Raffaele Spanò1

  • 1Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, 16163 Genoa, Italy.

Summary

Geometric patterning of poly(lactic-co-glycolic acid) (PLGA) films controls degradation and drug release. Higher surface area-to-volume ratios in micropatterned films enhance structural integrity and modulate release kinetics.