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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Updated: Jun 17, 2026

Biofunctionalization of Magnetic Nanomaterials
06:40

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Published on: July 16, 2020

Controlling nanoparticle targeting: from physicochemical design to molecular recognition.

Antonella Rocchi1, Luca Marchetti2, Paolo Decuzzi1,3

  • 1Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology, Genova, Italy.

Nanomedicine (London, England)
|June 16, 2026
PubMed
Summary

Nanomedicine utilizes innovative nanoparticles for targeted drug delivery, enhancing treatment precision and efficacy. Strategies leverage unique pathological features and nanoparticle properties for improved therapeutic outcomes.

Keywords:
Drug Delivery Systems (DDS)Nanoparticle targetingactive targeting ligandsbiological barriersstimuli-responsive nanocarrierstranslational nanomedicinetumor homing peptides, protein corona

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Last Updated: Jun 17, 2026

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Area of Science:

  • Nanomedicine and Drug Delivery
  • Biotechnology and Biomedical Engineering
  • Materials Science in Medicine

Background:

  • Nanoparticles offer advanced drug delivery, improving biodistribution, targeting, and therapeutic efficacy for various diseases.
  • Nanoparticle design integrates physicochemical properties with biological targeting mechanisms for enhanced performance.
  • Stimuli-responsive platforms exploit pathological tissue characteristics for controlled drug release and personalized medicine.

Purpose of the Study:

  • To critically examine nanoparticle targeting strategies in nanomedicine.
  • To discuss the advantages, limitations, and translational potential of different nanoparticle design approaches.
  • To explore how dynamic phenomena like protein corona formation influence nanoparticle behavior and targeting.

Main Methods:

  • Review and critical analysis of current nanoparticle targeting strategies.
  • Examination of physicochemical and biopharmaceutical properties influencing nanoparticle design.
  • Discussion of stimuli-responsive platforms and their exploitation of pathological microenvironments.

Main Results:

  • Nanoparticle design requires careful integration of material properties and biological targeting.
  • Stimuli-responsive systems offer precise payload release by exploiting disease-specific conditions.
  • Protein corona formation and immune responses present both challenges and opportunities for nanoparticle targeting.

Conclusions:

  • Targeting strategies are crucial for optimizing nanomedicine efficacy and safety.
  • Understanding dynamic nanoparticle-biological interactions is key for clinical translation.
  • Future nanomedicine development should focus on tailored nanoparticle design for personalized therapies.