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Updated: May 31, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
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Polyphosphazene Microcapsules Fabricated through Covalent Assembly.

Zhiqiang Feng1, Guoqiang Fan, Hongxia Wang

  • 1Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, and Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China.

Macromolecular Rapid Communications
|June 28, 2011
PubMed
Summary
This summary is machine-generated.

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Researchers created hollow polyphosphazene microcapsules using layer-by-layer assembly. These intact microcapsules are hydrolytically degradable in a phosphate buffer at biological pH.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Polyphosphazenes are versatile inorganic polymers with tunable properties.
  • Hollow microcapsules offer unique advantages for various applications due to their high surface area and low density.
  • Controlled fabrication of hollow microstructures is crucial for advanced material design.

Purpose of the Study:

  • To develop a method for fabricating hollow polyphosphazene microcapsules.
  • To characterize the structure and properties of the fabricated microcapsules.
  • To assess the hydrolytic degradability of the microcapsules under physiological conditions.

Main Methods:

  • Covalent layer-by-layer assembly of polydichlorophosphazene (PDCP) and hexamethylenediamine (HDA) on silica particles.

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Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
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  • Core removal using a hydrofluoric acid/ammonium fluoride (HF/NH(4)F) solution.
  • Characterization using transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), and FT-IR spectroscopy.

    • Main Results:

    • Successfully fabricated hollow and intact polyphosphazene microcapsules.
    • Confirmed the integrity of the microcapsules in both wet and dry states.
    • Verified the chemical structure and demonstrated hydrolytic degradability in a phosphate buffer at pH 7.4.

    Conclusions:

    • Hollow polyphosphazene microcapsules can be effectively fabricated using a layer-by-layer assembly approach.
    • The developed microcapsules exhibit structural integrity and are degradable under physiological conditions.
    • These findings open possibilities for using polyphosphazene microcapsules in biomedical or drug delivery applications.