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Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Inflammatory Response

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Related Experiment Video

Updated: Jun 17, 2026

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

Osteoclast-regulatory biomaterials: Direct cellular intervention and indirect microenvironment modulation.

Junzhang Ji1, Qiaoxuan Wang2, Changyou Gao3

  • 1Zhejiang Key Laboratory of Advanced Organic Materials and Technologies, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310058, China.

Biomaterials
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Biomaterials can regulate osteoclasts, cells central to bone diseases. Future biomaterials should be self-adaptive to better manage osteoclast activity in pathological conditions.

Keywords:
BiomaterialsCellular interventionMicroenvironment modulationOsteoclastOsteolysisSelf-adaptiveness

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Related Experiment Videos

Last Updated: Jun 17, 2026

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Pathology

Background:

  • Osteoclasts are key effector cells in osteolytic diseases, with their activity influenced by intrinsic and extrinsic factors.
  • Aberrant osteoclast activation contributes to various pathological bone conditions.
  • Current interventions for osteolytic diseases often target osteoclast activity.

Purpose of the Study:

  • To review current biomaterial strategies for regulating osteoclast activity.
  • To organize these strategies within a pathology-oriented framework.
  • To propose future directions for osteoclast-regulatory biomaterials, emphasizing self-adaptiveness.

Main Methods:

  • Literature review of osteoclast biology and biomaterial strategies.
  • Categorization of biomaterial approaches based on their regulatory mechanisms (direct/indirect).
  • Discussion of emerging evaluation platforms for biomaterial assessment.

Main Results:

  • Biomaterial strategies can directly regulate osteoclast commitment, maturation, function, and survival.
  • Indirect regulation involves modulating the osteoimmune, stromal, physicochemical, and organ-bone axes.
  • Self-adaptiveness is identified as a crucial future direction for enhanced pathological control.

Conclusions:

  • Biomaterials offer promising avenues for managing osteolytic diseases by targeting osteoclasts.
  • A pathology-oriented framework aids in understanding and designing effective biomaterial interventions.
  • Future biomaterials should incorporate self-adaptive properties for improved therapeutic outcomes in osteoclast-related disorders.