Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does insulin bolster antioxidant defenses via the extracellular signal-regulated kinases-protein kinase B-nuclear factor erythroid 2 p45-related factor 2 pathway?

Antioxidants & redox signaling·2011

Same author

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation.

Genes & development·2011

Same author

Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy.

Diabetes research and clinical practice·2011

Same author

JAMIE: A software tool for jointly analyzing multiple ChIP-chip experiments.

Methods in molecular biology (Clifton, N.J.)·2011

Same author

Morphine-induced conditioned place preference in mice: metabolomic profiling of brain tissue to find "molecular switch" of drug abuse by gas chromatography/mass spectrometry.

Analytica chimica acta·2011

Same author

[The interventions effect-assessment of the workers exposed to N, N-dimethylformamide by percutaneous in a synthetic leather factory].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2011

Search research articles

Related Experiment Video

Updated: May 31, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Genetically modified mesenchymal stem cells for improved islet transplantation.

Hao Wu¹, Zhaoyang Ye, Ram I Mahato

¹Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States.

Molecular Pharmaceutics

|June 29, 2011

Summary

Mesenchymal stem cells (MSCs) show promise for islet transplantation due to tissue regeneration and immune modulation. Genetic modification of MSCs may further enhance their therapeutic potential for treating diabetes.

Related Experiment Videos

Last Updated: May 31, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Area of Science:

Regenerative Medicine
Immunology
Endocrinology

Background:

Adult stem cells, particularly mesenchymal stem cells (MSCs) from bone marrow (BM), are increasingly used for therapeutic applications.
MSCs possess tissue regeneration and immune modulation properties beneficial for various diseases.
Recent applications include promoting revascularization, pancreatic beta-cell proliferation, and preventing allograft rejection in islet transplantation.

Purpose of the Study:

To review current challenges in islet transplantation.
To discuss the potential of primary and genetically modified MSCs in islet transplantation.

Main Methods:

Literature review focusing on MSCs and islet transplantation.
Analysis of MSC properties, including tissue regeneration and immune modulation.
Exploration of gene therapy applications in enhancing MSCs.

Main Results:

MSCs demonstrate therapeutic potential in promoting vascularization and immune tolerance.
Genetically modified MSCs can potentially amplify therapeutic benefits while maintaining stem cell characteristics.
Obstacles to successful islet transplantation are being addressed by novel cell-based therapies.

Conclusions:

MSCs offer a promising cell-based therapy for islet transplantation.
Genetic modification of MSCs represents a future direction to improve outcomes.
Further research is needed to fully elucidate the role of MSCs in overcoming islet transplantation barriers.