Related Experiment Video
Updated: May 31, 2026
14:49
Associated Chromosome Trap for Identifying Long-range DNA Interactions
Published on: April 23, 2011
A novel HLA-B*48 allele, B*48:01:03, identified by sequence-based typing
J-E Kang1, S-H Hwang, E-J Song
1Department of Laboratory Medicine, School of Medicine, Pusan National University, Busan, South Korea.
Tissue Antigens
|June 29, 2011
Summary
A novel Human Leukocyte Antigen (HLA) B allele, HLA-B*48:01:03, was identified. It differs from HLA-B*48:01:01 by a single nucleotide change at codon 269.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune response.
- Accurate HLA typing is essential for transplantation and disease association studies.
- Novel HLA allele discovery contributes to the understanding of immune diversity.
Purpose of the Study:
- To report the discovery and characterization of a new HLA-B allele.
- To document the specific genetic variation differentiating the new allele from a known one.
Main Methods:
- Nucleotide sequencing of the HLA-B gene.
- Comparison of the novel sequence with existing HLA allele databases.
Main Results:
- Identification of a new HLA-B allele designated HLA-B*48:01:03.
- The new allele, HLA-B*48:01:03, differs from HLA-B*48:01:01 by a single nucleotide substitution (CCC to CCT) at codon 269.
Conclusions:
- The discovery of HLA-B*48:01:03 expands the known HLA-B allele repertoire.
- This finding highlights the ongoing need for high-resolution HLA typing to capture genetic variations.
Related Concept Videos
02:20Blood Types
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
01:29Modern Molecular Taxonomy
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...