Related Experiment Video
Updated: May 31, 2026
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
[Photodynamic therapy and urothelial carcinoma]
Pierre Colin1, Juan Pablo Estevez, Nacim Betrouni
1Université Nord de France, unité U703, Inserm, 152, rue du Docteur-Yersin, 59120 Loos, France.
Purpose:
Photodynamic therapy (PDT) is an innovative therapeutic modality in urologic oncology.
Material And Methods:
We reviewed the current literature on principles and modalities of PDT in urothelial and penile oncology.
Results:
PDT has been tested for the treatment recurrent superficial bladder tumors and in situ carcinoma. Carcinologic efficacy has been observed with first generation photosensitizer. The lack of selectivity for tumoral cells was responsible of serious adverse events. Development of selective photosensitizers has reduced the importance of side effects. Data concerning PDT for upper urinary tract and urethra carcinoma are still limited.
Conclusion:
First PDT clinical applications in urothelial oncology have shown some effectiveness at the cost of significant morbidity. The development of selective photosensitizers should help to reduce side effects.
