Related Experiment Video
Updated: May 31, 2026
09:02
Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy in elderly patients
Antonio Macrì1, Edoardo Saladino, Giuseppe Trimarchi
1University of Messina, Department of Human Pathology, General Surgery Unit, Via Consolare Valeria, 98125 Messina, Italy.
In Vivo (Athens, Greece)
|June 29, 2011
Summary
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC) shows comparable survival rates for elderly patients with peritoneal malignancies. While higher grade morbidity and mortality were observed, the procedure is deemed suitable for this demographic.
Area of Science:
- Oncology
- Surgical Oncology
- Geriatric Medicine
Background:
- Peritoneal malignancies pose treatment challenges, particularly in elderly patients.
- Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a potential treatment, but carries significant surgical risks for older individuals.
Purpose of the Study:
- To evaluate the feasibility of CRS plus HIPEC in elderly patients (over 65 years).
- To assess postoperative morbidity, mortality, and survival outcomes in this patient group.
Main Methods:
- Retrospective analysis of 30 patients undergoing CRS plus HIPEC.
- Included patients with peritoneal carcinomatosis, advanced gastric cancer (T3-4), ECOG ≤2, and no bowel obstruction.
- Median follow-up was 21.5 months.
Main Results:
- Elderly patients experienced higher rates of grade 3 and 4 morbidity and mortality.
- Mean duration of surgery, postoperative hospital stay, and median/overall survival rates were similar between elderly and younger patients.
- No statistically significant differences in morbidity and mortality were found.
Conclusions:
- Despite higher initial morbidity and mortality, CRS with HIPEC is a viable treatment option for elderly patients with peritoneal malignancies.
- The procedure demonstrates comparable survival outcomes, suggesting suitability for this population.