Related Experiment Video

Updated: May 31, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Preconception cardiovascular risk factors and pregnancy outcome

Emily W Harville1, Jorma S A Viikari, Olli T Raitakari

  • 1Department of Epidemiology, Tulane University School of Public Health, New Orleans, LA, USA. eharvill@tulane.edu

Epidemiology (Cambridge, Mass.)
|June 29, 2011
PubMed

Insights

High preconception triglyceride levels increase the risk of hypertensive disorders and gestational diabetes during pregnancy. Improving maternal cardiovascular health before pregnancy may reduce these risks.

Area of Science:

  • Cardiovascular health
  • Reproductive medicine
  • Public health

Background:

  • Pregnancy complications are linked to adverse maternal and infant outcomes.
  • Preconception cardiovascular risk factors' impact on pregnancy is understudied.

Purpose of the Study:

  • To investigate the association between preconception cardiovascular risk factors and pregnancy complications.
  • To identify modifiable risk factors for improved pregnancy outcomes.

Main Methods:

  • Utilized data from the Cardiovascular Risk in Young Finns Study linked with birth registry data.
  • Analyzed preconception lipid profiles, blood pressure, insulin, and glucose levels.
  • Employed regression models to assess predictors of gestational age, birthweight, and pregnancy disorders.

Main Results:

  • Elevated triglyceride levels were associated with increased risk of hypertensive disorders and gestational diabetes.
  • Systolic blood pressure showed a trend towards predicting preterm birth and small-for-gestational-age infants.

Conclusions:

  • Preconception high lipid levels, particularly triglycerides, predict increased risk of preeclampsia and gestational diabetes.
  • Maternal pre-pregnancy conditions may explain links between pregnancy complications and later cardiovascular disease.
  • Interventions promoting preconception cardiovascular health could mitigate pregnancy complication risks.
Abstract

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...