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Updated: May 31, 2026

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

Subthalamic nucleus targeting using interpeduncular cistern as an internal landmark.

Milind Deogaonkar¹, Tiago Freitas, Andre Machado

¹Department of Neurosurgery, Cleveland Clinic Foundation, Center for Neurological Restoration, Cleveland, Ohio, USA. deoganm@ccf.org

|June 29, 2011

Summary

The width of the interpeduncular cistern (IPC) is a key factor in subthalamic nucleus (STN) deep brain stimulation (DBS) placement for Parkinson disease. This measurement can refine surgical targeting for improved outcomes.

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High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

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Last Updated: May 31, 2026

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

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Published on: October 2, 2015

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High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

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Published on: May 10, 2012

Area of Science:

Neurosurgery
Neurology
Medical Imaging

Background:

Traditional internal landmarks for subthalamic nucleus (STN) targeting in deep brain stimulation (DBS) exist.
This study introduces and validates a novel internal landmark for STN targeting.

Purpose of the Study:

To investigate the influence of interpeduncular cistern (IPC) width on STN targeting during DBS for Parkinson disease.
To establish the IPC width as a reliable internal landmark for precise electrode placement.

Main Methods:

Fifty Parkinson disease patients underwent 90 STN DBS implantations.
Measurements included IPC width, third ventricle width, and anterior commissure-posterior commissure length.
Statistical analysis employed linear regression and Pearson correlation.

Main Results:

The average IPC width was 7.59 mm (range: 5-14 mm).
IPC width significantly correlated with the mediolateral location of DBS electrode tips and active contacts (r=0.83, P=.0022).
A formula was derived: STN target X-coordinate = 0.6 × IPC width + 7 mm.

Conclusions:

Interpeduncular cistern width is a strong predictor of STN DBS electrode laterality in Parkinson disease.
IPC width serves as a valuable additional internal landmark for refining STN targeting.
This landmark can enhance the accuracy of DBS lead placement in Parkinson disease patients.