Zinc modulates copper coordination mode in prion protein octa-repeat subdomains

Francesco Stellato1, Ann Spevacek, Olivier Proux

  • 1Dipartimento di Fisica, Università di Roma Tor Vergata, Via della Ricerca Scientifica, 1, 00133, Rome, Italy.

Summary

Zinc ions compete with copper for binding to prion-protein peptides, revealing insights into metal binding competition and homeostasis. X-ray absorption spectroscopy (XAS) provided detailed structural information.

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