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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
Early bronchial involvement in children with allergic rhinitis
Giorgio Ciprandi1, Michele Capasso, Maria Angela Tosca
1Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy. gio.cip@libero.it
American Journal of Rhinology & Allergy
|June 30, 2011
Summary
In allergic rhinitis (AR) patients, a forced expiratory volume in 1 second (FEV(1)) cutoff of 83% effectively identifies early bronchial impairment. This spirometry finding is crucial for detecting potential asthma development in children with AR.
Area of Science:
- Pediatric Pulmonology
- Allergy and Immunology
- Respiratory Medicine
Background:
- Allergic rhinitis (AR) is frequently linked to asthma, potentially preceding its onset.
- Spirometry, particularly forced expiratory volume in 1 second (FEV(1)), is standard for asthma diagnosis.
- Forced expiratory flow at 25-75% (FEF(25-75)) <70% may indicate early bronchial involvement in AR.
Purpose of the Study:
- To evaluate a large cohort of children with AR.
- To define an FEV(1) value that corresponds to impaired FEF(25-75) values.
- To identify a spirometric marker for early bronchial changes in pediatric AR.
Main Methods:
- Studied 850 children with AR (555 boys, median age 10 years).
- Performed spirometry and skin-prick tests on all participants.
- Utilized descriptive statistics and multivariate analysis.
Main Results:
- 35.3% of patients exhibited FEF(25-75) values below 70% of predicted.
- Normal FEV(1) values were observed in conjunction with significantly impaired FEF(25-75).
- An FEV(1) cutoff value of 83% was identified.
Conclusions:
- Spirometry interpretation in AR patients requires careful consideration.
- An FEV(1) cutoff of 83% efficiently detects AR children with early bronchial impairment.
- This finding aids in the early identification of potential asthma development.
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