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Complicated Acute Rhinosinusitis in Cystic Fibrosis: National Inpatient Pediatric Analysis
Emily S Kwon1, Saharsh Talwar2, Annie Xu1
1Department of Otolaryngology-Head and Neck Surgery, Rutgers Health New Jersey Medical School, Newark, NJ, USA.
American Journal of Rhinology & Allergy
|August 5, 2026
Summary
Pediatric patients with cystic fibrosis (CF) hospitalized for acute rhinosinusitis (ARS) face longer stays and higher costs but fewer orbital complications. This study provides crucial data on ARS outcomes in CF patients.
Area of Science:
- Pediatric Otolaryngology
- Pulmonology
- Healthcare Outcomes Research
Background:
- No prior national data compared pediatric acute rhinosinusitis (ARS) hospitalizations between cystic fibrosis (CF) and non-CF patients.
- Understanding these differences is crucial for managing hospitalization burden and complication rates in pediatric CF patients.
Purpose of the Study:
- To compare complication risks and healthcare utilization in children hospitalized with ARS, differentiating between those with and without CF.
- To provide population-level data for clinicians managing pediatric ARS in the context of CF.
Main Methods:
- Analysis of inpatient admissions for pediatric ARS patients (2003-2019) from the Kids' Inpatient Database (KID).
- Comparison of outcomes including orbital/intracranial complications, sinus involvement, sinus procedures, length of stay, and hospital charges.
- Statistical analysis using weighted data to compare CF (1.5%) versus non-CF patients.
Main Results:
- CF patients had significantly lower odds of orbital complications (aOR 0.09) but higher odds of sinus procedures (aOR 1.59).
- CF patients experienced longer hospital stays (8 vs 3 days) and substantially higher hospital charges ($43,918 vs $11,129).
- Out of 41,148 weighted ARS patients, 632 (1.5%) had CF.
Conclusions:
- Children with concurrent CF and ARS exhibit a greater disease burden, indicated by prolonged hospitalizations and increased healthcare costs.
- CF patients hospitalized for ARS appear to have a reduced risk of orbital complications compared to their non-CF counterparts.
- Findings highlight the need for tailored management strategies for pediatric ARS in CF patients, balancing complication risks and resource utilization.
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