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Related Experiment Video

Updated: May 31, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

[Amoxicillin-induced hepatitis].

Jakob Oxlund¹, Alan Hamilton Ferguson

¹Anæstesiologisk Afdeling, Sydvestjysk Sygehus Esbjerg, Denmark. jakoboxlund@hotmail.com

Ugeskrift for Laeger

|June 30, 2011

Summary

Amoxicillin alone, a common antibiotic, can cause drug-induced hepatitis, even when used prophylactically. This case highlights a rare but serious side effect not typically listed in Danish medical references.

Area of Science:

Pharmacology
Hepatology
Infectious Disease

Background:

Amoxicillin, with or without clavulanic acid, is a frequently prescribed antibiotic for both therapeutic and prophylactic purposes in diverse patient populations.
Hepatotoxicity is not commonly associated with amoxicillin monotherapy in Danish medical literature, including resources like medicin.dk and Lægemiddelkataloget.

Observation:

A 61-year-old male patient received amoxicillin without clavulanic acid for prophylactic treatment following a tick bite.
Twenty days after initiating the antibiotic treatment, the patient developed symptoms indicative of drug-induced hepatitis.

Findings:

The presented case demonstrates a rare instance of amoxicillin monotherapy leading to pharmacologically induced hepatitis.
This finding contrasts with the established understanding and documentation of amoxicillin's side effect profile in Denmark.

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Implications:

This case underscores the importance of considering amoxicillin-induced hepatitis as a potential diagnosis, even in the absence of typical reporting.
Clinicians should maintain awareness of rare adverse drug reactions, particularly when treating patients with antibiotics.
Further investigation into the mechanisms and incidence of amoxicillin-related hepatotoxicity may be warranted.