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Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
Published on: May 18, 2017
Emerging issues with the current keratin-associated protein nomenclature
Hua Gong1, Huitong Zhou, Grant W McKenzie
1Gene Marker Laboratory, Faculty of Agricultural Sciences, Lincoln University, NewZealand.
International Journal of Trichology
|June 30, 2011
Summary
Keratin associated proteins (KAPs) are crucial for fiber properties but lack a universal naming system. This paper argues for a revised nomenclature to address this long-standing issue.
Area of Science:
- Biochemistry
- Proteomics
- Materials Science
Background:
- Keratin associated proteins (KAPs) are essential structural proteins.
- KAPs form disulphide linkages with keratin intermediate filaments, imparting unique properties to fibers like hair and wool.
- Over 90 KAP proteins across 25 families have been identified, excluding polymorphic variants.
Purpose of the Study:
- To highlight the lack of a universally accepted nomenclature for Keratin Associated Proteins (KAPs).
- To present a case for revising the current KAP naming system.
- To address the long-standing issue of KAP nomenclature.
Main Methods:
- Literature review of existing KAP research.
- Analysis of current naming conventions and their limitations.
- Proposal for a revised nomenclature system.
Main Results:
- The diversity of KAPs (over 90 proteins) complicates existing naming.
- The absence of a unified nomenclature hinders research and communication.
- A revised system is necessary to accurately classify and name KAP families and variants.
Conclusions:
- A standardized nomenclature for Keratin Associated Proteins is urgently needed.
- Revising the current system will facilitate clearer scientific communication and research.
- Implementing a new nomenclature will improve the understanding of fiber structure and properties.
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