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The optimal surgical treatment for primary hyperparathyroidism in MEN1 patients: a systematic review
Jennifer M J Schreinemakers1, Carolina R C Pieterman, Anouk Scholten
1Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
Background:
The optimal surgical approach for patients with primary hyperparathyroidism (pHPT) and multiple endocrine neoplasia 1 (MEN1) is controversial. We sought to determine the optimal type of surgery for pHPT in MEN1.
Methods:
We collected data on clinical presentation, surgery, and follow-up for MEN1 patients with pHPT at the University Medical Center Utrecht and affiliated hospitals between 1967 and 2008. Furthermore, we performed a systematic review of the literature and meta-analysis. Surgical procedures were classified into less than subtotal (
Results:
Fifty-two patients underwent primary surgery for pHPT, of which 29 had
Conclusion:
We believe that SPTX is the best surgical therapy for pHPT in MEN1. MEN1 patients with pHPT should not be treated with
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