Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 31, 2026

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy
08:23

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy

Published on: November 10, 2023

Lung morphometry with hyperpolarized 129Xe: theoretical background.

A L Sukstanskii1, D A Yablonskiy

  • 1Department of Radiology, Washington University, St. Louis, Missouri, USA. alex@wuchem.wustl.edu

Magnetic Resonance in Medicine
|June 30, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concise derivation of oscillating-gradient-derived ADC.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2018
Same author

Exact analytical results for ADC with oscillating diffusion sensitizing gradients.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2013
Same author

Magnetic susceptibility induced white matter MR signal frequency shifts--experimental comparison between Lorentzian sphere and generalized Lorentzian approaches.

Magnetic resonance in medicine·2013
Same author

Morphometric changes in the human pulmonary acinus during inflation.

Journal of applied physiology (Bethesda, Md. : 1985)·2011
Same author

Imaging alveolar-duct geometry during expiration via ³He lung morphometry.

Journal of applied physiology (Bethesda, Md. : 1985)·2011
Same author

³He lung morphometry technique: accuracy analysis and pulse sequence optimization.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2010
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026
See all related articles

A new MRI technique using hyperpolarized xenon-129 gas can measure lung microstructure at the alveolar level. This method provides detailed lung imaging for both humans and small animals, aiding in the assessment of lung diseases like emphysema.

Area of Science:

  • Medical Imaging
  • Pulmonary Medicine
  • Biophysics

Background:

  • Hyperpolarized helium-3 (He) MRI enables lung morphometry by measuring gas diffusion in airspaces.
  • This technique yields in vivo 3D images of alveolar-level microstructure, including airspace chord length and surface-to-volume ratio.
  • Current methods rely on He-3 diffusion theory and MRI signal analysis.

Purpose of the Study:

  • To develop a theoretical framework for lung morphometry using hyperpolarized xenon-129 (Xe-129) gas.
  • To adapt existing He-3 based MRI techniques for Xe-129, considering its different diffusion and gyromagnetic properties.
  • To establish relationships between lung geometry and Xe-129 diffusion-attenuated MRI signals.

Main Methods:

  • Theoretical modeling of Xe-129 gas diffusion in lung acinar airways.

More Related Videos

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
09:08

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Published on: November 21, 2023

Related Experiment Videos

Last Updated: May 31, 2026

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy
08:23

Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy

Published on: November 10, 2023

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
09:08

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Published on: November 21, 2023

  • Experimental MRI measurements of diffusion-attenuated signals in human and animal lungs.
  • Application of Bayesian probability theory to estimate measurement uncertainties.

    • Main Results:

    • Phenomenological relationships were established between lung morphometry and Xe-129 diffusion MRI signals.
    • Optimal diffusion times were determined: approximately 5 ms for human lungs and 1.3 ms for small animal lungs.
    • The technique is applicable to both normal lungs and those with mild emphysema.

    Conclusions:

    • Hyperpolarized Xe-129 MRI offers a viable alternative for lung morphometry.
    • This technique provides unique insights into lung microstructure at the alveolar level.
    • The developed method has potential for diagnosing and monitoring lung diseases.