Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of and risk factors for diabetic retinopathy: The Thessaloniki Eye Study.

Eye (London, England)·2026
Same author

The Future of Glaucoma: Data, AI, and Precision Medicine for Patient-Centered Care.

Journal of glaucoma·2026
Same author

Ocular blood flow and retinal oxygen saturation measurements in central retinal artery occlusion.

Acta ophthalmologica·2026
Same author

Real-world integration of an autonomous artificial intelligence system for diabetic retinopathy screening in an endocrinology outpatient clinic.

The British journal of ophthalmology·2026
Same author

Stresses and fluid flow in lamina cribrosa through anisotropic poroelasticty.

ArXiv·2026
Same author

Stresses and fluid flow in lamina cribrosa through anisotropic poroelasticity.

Biomechanics and modeling in mechanobiology·2026
Same journal

Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.

Investigative ophthalmology & visual science·2026
Same journal

Psychometric Performance of Children With Amblyopia During a Tablet-Based Adaptive Visual Acuity Assessment.

Investigative ophthalmology & visual science·2026
Same journal

The Molecular Basis of Ocular Aging: Mechanisms, Pathologies, and Emerging Therapeutics.

Investigative ophthalmology & visual science·2026
Same journal

Sensory Eye Dominance Remains Stable Across Binocular Combination and Rivalry in Normal and Anisometropic Amblyopic Vision.

Investigative ophthalmology & visual science·2026
Same journal

Exosome-Associated Gene Network and the Role of SPP1 in Herpes Stromal Keratitis and the Therapeutic Modulation by Ursolic Acid.

Investigative ophthalmology & visual science·2026
Same journal

Nonlinear Associations of Estimated Glucose Disposal Rate With Incident Age-Related Eye Diseases: Implications for Metabolic Risk Stratification.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Retinal oximetry in primary open-angle glaucoma.

Olof Birna Olafsdottir1, Sveinn Hakon Hardarson, Maria Soffia Gottfredsdottir

  • 1Department of Ophthalmology, University of Iceland, Reykjavik.

Investigative Ophthalmology & Visual Science
|July 1, 2011
PubMed
Summary
This summary is machine-generated.

Primary open-angle glaucoma (POAG) affects retinal vessel oxygen saturation. Deeper visual field defects correlate with higher venule oxygen saturation and lower arteriovenous oxygen differences in POAG patients.

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Related Experiment Videos

Last Updated: May 31, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Retinal Physiology
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Understanding the physiological changes in the retina associated with POAG is crucial for disease management.
  • Retinal vessel oxygen saturation is a potential indicator of ocular tissue metabolism.

Purpose of the Study:

  • To investigate whether retinal vessel oxygen saturation is altered in patients diagnosed with primary open-angle glaucoma.
  • To explore the relationship between the severity of visual field defects and retinal oxygen saturation levels in POAG.
  • To assess potential alterations in retinal oxygen metabolism in the context of POAG.

Main Methods:

  • Retinal oxygen saturation was measured in the arterioles and venules of POAG patients using a spectrophotometric retinal oximeter in a dark environment.
  • Visual field testing was conducted to quantify the extent of visual field defects.
  • Oxygen tension (Po(2)) was calculated from the measured oxygen saturation values.
  • Statistical analyses, including Pearson's correlation and Student's t-test, were employed to analyze the data.

Main Results:

  • A higher mean oxygen saturation was observed in venules of POAG patients with poorer visual fields (68% ± 4%) compared to those with good visual fields (62% ± 3%; P = 0.0018).
  • The mean arteriovenous difference in oxygen saturation was significantly lower in patients with poor visual fields (30% ± 4%) versus good visual fields (37% ± 4%; P = 0.0003).
  • Oxygen saturation in retinal venules showed a positive correlation with the worsening of visual field mean defect (r = 0.43; P = 0.015), while the arteriovenous difference decreased as visual field defects worsened (r = -0.55; P = 0.0013).

Conclusions:

  • Deeper glaucomatous visual field defects are associated with increased oxygen saturation in retinal venules and a reduced arteriovenous oxygen saturation difference.
  • These findings suggest that oxygen metabolism is indeed affected in the glaucomatous retina.
  • The observed changes in retinal oxygen saturation may be linked to underlying tissue atrophy in primary open-angle glaucoma.