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Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools
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Published on: June 20, 2020

FFAS server: novel features and applications.

Lukasz Jaroszewski1, Zhanwen Li, Xiao-hui Cai

  • 1Bioinformatics and Systems Biology Program, Sanford Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

Nucleic Acids Research
|July 1, 2011
PubMed
Summary
This summary is machine-generated.

The updated Fold and Function Assignment System (FFAS) server enhances protein profile-profile alignments with expanded databases and improved visualization tools. This powerful bioinformatics resource offers faster analysis for protein function prediction and structural analysis.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Structural Biology

Background:

  • The Fold and Function Assignment System (FFAS) server implements a protein profile-profile alignment algorithm.
  • Previous versions of FFAS were released in 2005.

Purpose of the Study:

  • To present updates, new functionalities, and applications of the FFAS server since 2005.
  • To improve protein sequence analysis and function prediction capabilities.

Main Methods:

  • Enriched the sequence database with metagenomic sequences.
  • Added new profile databases (complete proteomes, human disease proteins, microbial virulence factors).
  • Developed a new tabbed interface with enhanced visualization tools (dotplot viewer, 3D alignment viewer).

Main Results:

  • FFAS server performance was optimized, reducing running times by an order of magnitude.
  • New databases enable broader comparisons for protein analysis.
  • Improved interface enhances user experience and data navigation.

Conclusions:

  • The updated FFAS server provides a significantly enhanced platform for protein profile-profile alignment.
  • Novel features and expanded databases facilitate more comprehensive protein function and structure analysis.
  • The FFAS server remains a freely accessible and valuable tool for the scientific community.