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Related Experiment Video

Updated: May 31, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Postoperative cognitive disorders.

Terri G Monk1, Catherine C Price

  • 1Department of Anesthesiology, Duke University Medical Center, Durham Veterans Administration Medical Center, Durham, North Carolina, USA. Terri.Monk@duke.edu

Current Opinion in Critical Care
|July 1, 2011
PubMed
Summary
This summary is machine-generated.

Postoperative cognitive problems like delirium and POCD are common in elderly surgical patients. Emerging evidence suggests preoperative cognitive function and interventions can mitigate these risks, but more research is needed.

Related Experiment Videos

Last Updated: May 31, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Area of Science:

  • Geriatric Medicine
  • Anesthesiology
  • Neuroscience

Background:

  • The elderly population is rapidly growing and accounts for a significant portion of surgical procedures.
  • Postoperative cognitive problems, including delirium and postoperative cognitive dysfunction (POCD), are prevalent in older surgical patients.
  • These cognitive disorders have substantial socioeconomic impacts, affecting independence, quality of life, and mortality.

Purpose of the Study:

  • To review the common postoperative cognitive problems in the elderly: delirium and POCD.
  • To discuss current and emerging interventions for preventing and managing these conditions.
  • To highlight the need for further research into the etiology and treatment of postoperative cognitive issues.

Main Methods:

  • Review of recent publications on interventions for postoperative delirium and POCD.
  • Analysis of factors predicting risk, such as cognitive reserve and white matter integrity.
  • Discussion of potential neurotoxicity of anesthetic agents.

Main Results:

  • Preoperative geriatric consultation was historically the only proven intervention for delirium.
  • Recent evidence suggests preoperative/postoperative medical and pharmacological management can reduce delirium.
  • Spinal anesthesia and dexmedetomidine sedation show promise in reducing delirium incidence and duration.

Conclusions:

  • The exact causes of postoperative cognitive problems remain unclear, but reduced preoperative cognitive function appears to be a contributing factor.
  • While inhalation anesthetics are suspected to be neurotoxic to aging brains, human data is lacking.
  • Urgent need for randomized controlled trials to evaluate interventions for improving long-term cognitive outcomes in elderly patients.