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Updated: May 31, 2026
Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells
Published on: July 22, 2015
Photolon enhancement of ultrasound cytotoxicity
D A Tserkovsky1, E N Alexandrova, Yu P Istomin
1N.N. Alexandrov National Cancer Center of Belarus, 223040 Minsk, Belarus.
Objective:
To evaluate the impact of Photolon on cytostatic and cytotoxic effects of therapeutic range ultrasound in C6 glioma cells.
Methods:
C6 glioma cells in suspension or monolayer cell culture were exposed to ultrasound (880 kHz, 0.2-0.7 W/cm2) in the presence or absence of Photolon at the concentration of 1 μg/ml in the culture medium, and then cell viability was evaluated.
Results:
Photolon increased the cytotoxic effect of ultrasound by 1.5-2.3-fold but had no effect on its cytostatic activity.
Conclusion:
Photolon produces a pronounced sonosensitizing effect on glioma C6 cells and is a promising drug for sonodynamic treatment of malignant tumors.
