Related Experiment Video
Updated: May 31, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Improvement of absorption and scattering discrimination by selection of sensitive points on temporal profile in
Farouk Nouizi1, Murielle Torregrossa, Renee Chabrier
1Laboratoire d’Imagerie et de Neurosciences Cognitives, UMR 7237, Université de Strasbourg/CNRS, 4 rue Kirschleger, 67085 Strasbourg Cedex, France. farouk.nouizi@unistra.fr
Abstract:
We present a new method allowing the reconstruction of 3D time-domain diffuse optical tomography images, based on the time-dependent diffusion equation and an iterative algorithm (ART) using specific points on the temporal profiles. The first advantage of our method versus the full time-resolved scheme consists in considerably reducing the inverse problem resolution time. Secondly, in the presence of scattering heterogeneities, our method provides images of better quality comparatively to classical methods using full-time data or the first moments of the profiles.

